The Sinclair Method

How It Works

Disrupt the urge to drink with safe, FDA approved medication.

With the Sinclair Method you’ll start by mapping out your alcohol drinking pattern. Once you know your alcohol use, you’ll take a naltrexone pill about two hours before each drinking session, and you’ll avoid taking naltrexone at any other time.

Naltrexone is a safe, FDA approved medication that blocks endorphin activity.

By pairing naltrexone with each drinking session, your body and brain will start to relearn that drinking alcohol doesn’t provide the same positive reinforcement as before, since endorphin activity from drinking is blocked by the naltrexone.

You’ll repeat the step of always taking a naltrexone pill before drinking consistently, and in a few weeks to a few months you’ll start to notice a growing indifference toward alcohol as your cravings and strong desire for alcohol continue to go away.

“Medication assisted treatment with naltrexone, the Sinclair Method, appears to be the most effective treatment for alcohol use disorder at this time.”


Clifford Fields, D.O., Emergency and Addiction Medicine

Program Features

Video Chat Sessions

You’ll start with an initial medical assessment with your Alcure medical provider.

As you progress through treatment you’ll have unlimited access to your Alcure provider by video chat and email for guidance to optimize treatment.

Our platform comes with robust security and privacy for video chat sessions and you can video chat from any device.

Step-By-Step Courses

We’ll give you access to our video tutorials and courses which are divided into three modules.

The first module walks you through Sinclair Method dosing protocol so you’ll become a pro at medication dosing compliance, key to success.

The second module shows you how to harness a phase called “upregulation”, which is when the medication eliminates from your body. During the upregulation phase, healthy behaviors are reinforced because your body is more sensitive to endorphin-backed activities.

The third module curates wellness principles to help you neutralize secondary causes of excess drinking. Our third module is the most comprehensive and covers a wide variety of topics.

Ongoing Support

Some clients will require an increase in medication dosage, some a temporary decrease and others repeat medication dosing when they drink.

Each client is different and by having your Alcure medical provider monitor your progress, you’ll make adjustments so you can reach your desired goal in the quickest time possible.

Reduce Drinking Alcohol Lifestyle

Your New Lifestyle

Clients usually report a growing indifference toward alcohol as they progress.

Once clients reach their goal they move onto the maintenance stage of Sinclair Method treatment.

That involves periodic check-ins with your Alcure medical provider for a reassessment and refill of your naltrexone medication.


Alcohol Consumption Induces Endogenous Opioid Release in the Human Orbitofrontal Cortex and Nucleus Accumbens

This 2012 Mitchell study, out of the University of San Francisco, proved that alcohol releases endorphins (also called “endogenous opioids”) which are the body’s naturally produced version of an opioid that simply reinforce the act of drinking. Using naltrexone, which we prescribe to our clients for targeted dosing to disrupt that reinforcement, is the basis of the Sinclair Method.

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Evidence about the use of naltrexone and for different ways of using it in the treatment of alcoholism

This 2001 study, put out by the Finnish National Public Health Institute and authored by the scientist that invented the “Sinclair Method,” explains the basics of what’s called “Pharmacological Extinction” in the medical literature and how it employs the targeted dosing of naltrexone to achieve extinction of alcohol use disorder.

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Efficacy of As-Needed Nalmefene in Alcohol-Dependent Patients with at Least a High Drinking Risk Level: Results from a Subgroup Analysis of Two Randomized Controlled 6-Month Studies

This more recent European medical journal article summarizes two large-scale patient studies testing the targeted dosing of a second-generation opioid-blocker similar to naltrexone to achieve similar results in extinguishing alcohol use disorder as the Finnish studies produced. In 2014, Pharmacological Extinction combined with therapy was officially approved by the European Union’s version of the FDA as an effective treatment model and is now widely available for treating alcohol use disorder in other European countries besides just Finland.

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GABA receptors and alcohol

This 2009 study, from the Waggoner Center for Alcohol and Addiction Research in Texas, explains how the alcohol molecule also “mimics” GABA, a naturally occurring neurochemical that slows neuronal firing to produce a calming effect, the reason many people drink. Opioid-blocking medication doesn’t block GABA, making extinction of alcohol use disorder relatively effortless. How? The overall “drinking experience” is not affected. Just the endorphins are blocked, a less noticeable effect.

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The BRENDA model: integrating psychosocial treatment and pharmacotherapy for the treatment of alcohol use disorders

This 2006 study from the University of Pennsylvania explains how support improves the outcome of medication-assisted treatment of alcohol use disorder by assisting patients in understanding treatment protocol and compliance. Support also assists patients with neutralizing secondary causes of alcohol use disorder that usually brought about the condition in the first instance.

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Effects of short deprivation and re-exposure intervals on the ethanol drinking behavior of selectively bred high alcohol-consuming rats

This 2008 study, from the University of Indianapolis, explains the “alcohol deprivation effect,” which is nearly identical to “yo-yo” dieting for people attacking a weight issue through will-power alone. With alcohol use disorder we call this “relapse.” Our treatment method will eliminate relapse once you cement the habit of as-needed use of the medication we prescribe any time you choose to drink in the future. It’s easy to do. The chart below demonstrates the basic “yo-yo” trajectory of drinking caused by the alcohol deprivation effect. Time periods in which cravings rise due to forced abstinence will vary in length.

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The “Yo-Yo” Trajectory

Reduce Alcohol Consumption